David J. The liver is a primary target for the action of GH, a pituitary protein hormone that regulates a broad range of physiological processes, including long bone growth, fatty acid oxidation, glucose uptake, and hepatic steroid and foreign compound metabolism. GH exerts sex-dependent effects on the liver in many species, with many hepatic genes, most notably genes coding for cytochrome P CYP enzymes, being transcribed in a sex-dependent manner. Sex differences in CYP expression are most striking in rats and mice up to fold male-female differences , but are also seen, albeit to a much smaller degree, in humans, where they are an important determinant of the sex dependence of hepatic drug and steroid metabolism. This article examines the mechanisms whereby GH, via its sex-dependent temporal patterns of pituitary release, activates intracellular signaling leading to the sexually dimorphic transcription of CYPs and other liver-expressed genes.
Short-term fasting abolishes the sex-related difference in GH and leptin secretion in humans
GH Sex Abbreviation
The morphogenesis of the murine pituitary is initiated by neurulation and continues throughout embryonic development where it is under the influence of numerous critically timed signaling pathways that lead to the differentiation and proliferation of the individual endocrine cell populations Rizzoti The earliest exclusive pituitary marker is PROP1 , a paired homeodomain transcription factor, which is expressed at embryonic day 10 E10 in the mouse. On E Postnatal expression of Pou1f1 is maintained for the expansion and survival of these cell types and to regulate the expression of hormones and hypothalamic peptide receptors Olson et al.
Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice
Top definition. GH has 3 meanings. Good half: Used to indicate in sports that a team did good in a certain half of the game, either the 1st or last half. It is considered bad to be good at the first yet bad at the second as this indicates choking and losing the game after gaining a lead.
No significant correlation was found in either group between the basal plasma estradiol or testosterone levels and the maximum or integratedGH response to GHRH. Recent in vivo and in vitro data reveal a similar sex difference in rodents and an enhancing effect of androgens, but not estrogens, on the GH response to GHRH. These findings support the theory that in humans testosterone also plays a key role in the genesis of this sex difference. Most users should sign in with their email address.